Guiding a mutator in antibody diversification
نویسندگان
چکیده
منابع مشابه
A Common Mechanism that Underpins Antibody Diversification
Targeting of AID to antibody variable (V) regions results in somatic hypermutation, whereas its recruitment to switch (S) regions leads to class-switch recombination. Yeap et al. find that the mechanism by which variable and switch regions recruit AID essentially is the same but that the two regions differ in the density of double-stranded DNA breaks that are generated. These lead to either poi...
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PONTANEOUS mutation is a well known phenomenon. A mutation is S considered spontaneous when it cannot be traced back to some agent which is known to influence mutability. The causes of “spontaneous” mutation can be investigated when strains are found which differ noticeably in their inherent mutability. Recently, high mutation frequency in a strain of D. pseudoobscura, race B, was found to be d...
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We have proposed that an early step in tumor progression is the expression of a mutator phenotype resulting from mutations in genes that normally function in the maintenance of genetic stability. There is new and strong experimental evidence that supports the concept of a mutator phenotype in cancer. As technologies for chromosomal visualization and DNA advance, there are increasing data that h...
متن کاملR Loops in the Regulation of Antibody Gene Diversification
For nearly three decades, R loops have been closely linked with class switch recombination (CSR), the process that generates antibody isotypes and that occurs via a complex cascade initiated by transcription-coupled mutagenesis in switch recombination sequences. R loops form during transcription of switch recombination sequences in vitro and in vivo, and there is solid evidence that R loops are...
متن کاملSecondary mechanisms of diversification in the human antibody repertoire
V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges. V(D)J recombination efficiently generate a virtually limitless diversity through random recombination of variable (V), diversity (D), and joining (J) genes with div...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2018
ISSN: 1001-0602,1748-7838
DOI: 10.1038/s41422-018-0085-8